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How to Keep the Weight Off After Ozempic: LIVation's Guide

There’s a reason everyone’s talking about semaglutide—it changes lives. This weekly shot helps people shed excess weight, manage blood sugar, and reduce risk of cardiovascular disease and complications, all of which help patients live fuller, more rewarding lives. Semaglutide weight loss shots have been an invaluable tool at LIVation in supporting our patients’ health and wellness journeys and one of our most popular treatments.


But what happens after you stop taking semaglutide, whether it’s compounded semaglutide or a brand name product like Ozempic or Wegovy? A lot of people believe that you have to stay on semaglutide for the rest of your life, and while some people may need to or want to, you can certainly stop taking it. However, there is a risk that you could gain weight. Discontinuing semaglutide will cause your brain and body to revert to how it originally responded to food, and if you’re not prepared, you may fall back into bad habits. Here, we share our tips for maintaining weight loss after stopping semaglutide—and remember, the team at LIVation is here to help you every step of the way. 


Understanding Post-Ozempic Weight Dynamics


Semaglutide helps people lose weight by making them feel fuller faster and longer than they normally would without the drug. It also helps curb cravings. As you taper off, you may find that cravings return and you’ll feel the need to eat more in order to feel full. If semaglutide was helping you manage your blood sugar, ceasing taking it will mean your blood sugar won’t be regulated. For many people, these changes can cause rebound weight gain, with some gaining all of the weight, if not more, that they lost when taking semaglutide. Understanding these changes are the first step towards maintaining the results you achieved with the help of semaglutide.


Holistic Weight Management Strategies Beyond Semaglutide


To help maintain your semaglutide weight loss, there are some critical steps to take. And while we know you’ve likely heard this your whole life, staying hydrated is essential to weight loss. The most obvious reason for this is that drinking water can help you feel fuller, which may help prevent you from overeating or drinking excess liquid calories (like soda or other sugary drinks). But drinking water can do so much more than that. Water is key to your body’s ability to metabolize fat, whether that’s stored fat or fat found in food and drink. Studies show that drinking more water can increase your rate of weight loss. Drinking water also helps your body clear waste, including toxins that are filtered by and held in the kidneys. When your body is dehydrated, your kidneys retain fluid. You may also face issues with constipation, or experience bloating. Flushing your body by consuming enough water can help you shed weight caused by waste retention.


You may be wondering how electrolytes play a role in body hydration. Electrolytes are important nutrients that help control fluid balance in your body, support muscle contractions, and even support your blood sugar. Those people who struggle to drink enough water or get enough nutrients in their diet when taking semaglutide (which is not uncommon, as those taking semaglutide consume less overall) may have depleted electrolyte levels, which can result in nausea, fatigue, cognitive issues, blood pressure fluctuations, heart concerns, and more. At LIVation, we offer LMNT electrolyte powder packets in a variety of flavors to mix into water before drinking, which will help to instantly boost your body’s electrolyte levels and restore balance in your body.


You should also be maintaining a consistent exercise routine. Doing this while taking semaglutide was important because without strength training, the shrinking number you see on the scale could be due to muscle loss, not just fat loss. Muscle burns more calories than fat and can only be gained through strength training. If you lose too much muscle and don’t build it up with resistance training, you’ll burn fewer calories—and if you’re trying to control an insatiable appetite after quitting semaglutide, this can make it easy to put the weight back on. 


Integrating Emsculpt NEO in Your Post-Ozempic Regimen


In addition to following a consistent workout routine to build muscle, you can try Emsculpt NEO, a go-to treatment of our patients at LIVation. Emsculpt is an innovative device powered by radiofrequency and muscle-stimulating technology that helps grow muscle while burning fat. This treatment can be used on the abs, glutes, thighs, arms, and more areas to counteract muscle loss, which will support your body’s ability to burn calories and promote lasting weight loss as well as enhance the results of your weight loss from semaglutide. 


Combining Semaglutide with Nutritional Guidance at LIVation


Beyond fitness and hydration, following a healthy diet is the most important aspect of maintaining weight loss. Because semaglutide helps to control cravings and prevent overeating, it can be challenging to stick to your goals and eat things that supply your body with essential nutrients rather than junk food. 


Figuring out how to eat without the help of semaglutide can be one of the greatest challenges our patients face after stopping the drug. We urge you to rely on us! At LIVation, our licensed medical providers can work with you to create a nutritional plan to ensure your body is getting the vitamins and minerals it needs without overdoing it. That plan may include lean proteins, leafy greens, and complex carbohydrates, depending on your dietary restrictions.


We formulate our compounded semaglutide with amino acid l-carnitine. This nutrient helps your body convert fatty acids into energy. We often recommend that our semaglutide patients supplement their injections with oral l-carnitine. Following this regimen is even more important once getting off semaglutide. We sell Designs For Health Carnitine Synergy, which combines l-carnitine with another form known as acetyl-l-carnitine, which supports brain health and function.


The Role of Personalized IV Therapy in Weight Maintenance


As mentioned, keeping your body hydrated greatly facilitates weight loss, whether you’re on semaglutide or off. LIVation’s origins are in IV therapy and integrating regular IV drips into your wellness routine are a great way to support the results of your weight loss from semaglutide. Our signature IV infusion therapy options  will flood your body with hydration as well as vitamins, minerals, and more nutrients to help your body function at its peak. Talk to our providers about how custom IV therapy can help you maintain your weight loss after taking Ozempic, Wegovy, or compounded semaglutide.


Maintenance Doses of Semaglutide


Everyone needs a little boost now and again. If you find yourself falling into old patterns or are struggling to manage your weight during a challenging period in your life, there’s no shame in visiting us for a maintenance dose. Many of LIVation’s semaglutide patients—as well as our founders!—choose to get semaglutide weight loss shots every few weeks rather than every week. This keeps low levels of the drug in your system, which still helps reduce your cravings and keep you feeling fuller longer, but won’t create as strong of an effect as a weekly dose would. 


LIVation's Approach to Affordable, Long-Term Health Solutions


At our clinic on the Connecticut shoreline, we offer a variety of health and wellness treatments to help our patients look and feel their best. We welcome you to contact us today to learn how we can support you on your journey and help you achieve your goals. 

By Joseph Baczewski February 19, 2025
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One of the most popular treatments we offer at LIVation is semaglutide , a weight loss shot that is manufactured under the brand names Ozempic and Wegovy. Countless patients have lost hundreds of pounds with our US-manufactured peptide blend, including our team— our founder Joe lost 56 pounds in just six months! However, that’s not the only weight loss injection we offer. In addition to semaglutide and tirzepatide (also known as Mounjaro and Zepbound), we offer retatrutide, a brand new treatment that has been shown to offer the most advanced benefits of any weight loss shot to date. How Retatrutide Weight Loss Shots Work Retatrutide is a drug that works similarly to semaglutide and tirzepatide, but works in three different ways. Semaglutide targets your receptor of the GLP-1 hormone, which stabilizes your blood sugar, helping to reduce cravings while helping you to eat less, as well as slowing down your digestive system to help you feel fuller longer. Tirzepatide targets both the GLP-1 receptor as well as that of the GIP, which gives it a metabolic boosting factor that creates a better modality and efficiency for cell energy production. This makes it exceptional at helping with targeted fat loss. It also helps protect your muscles as well as limit nausea. Retatrutide, however, targets three different receptors—GLP-1, GIP, and glucagon—further helping you to feel less hungry and working to prevent overeating. At LIVation, we often start patients on semaglutide and transition them to tirzepatide if they are facing intolerable side effects or have hit a plateau with their weight loss. Semaglutide remains our most popular weight loss injection option. However, for those who have hit a plateau with tirzepatide, still are experiencing uncomfortable side effects, or simply want to try the newest and most advanced weight loss shot option, we offer retatrutide. The Benefits of Retatrutide Weight Loss Shots From LIVation Having taken it ourselves, we can confirm that this medication offers the fewest side effects, rapid weight loss, and even gave us a boost in energy, though your experience may vary. And while we’ve been impressed by what we’ve seen from retatrutide here at our Madison, CT clinic, the science confirms that this weight loss shot is highly effective. In June 2023, The New England Journal of Medicine published clinical trial results showing that after taking retatrutide for 48 weeks, overweight and obese patients lost about 24 percent of their body weight, results that surpass those of semaglutide and tirzepatide. Though retatrutide is not yet FDA approved, the phase III clinical trial of this weight loss injection is currently underway, which means you can expect it to receive FDA approval sometime in 2026 or 2027. However, the treatment does not have to be FDA approved for us to know that the drug can be used safely. This science and peptide technology has been around for decades—it is the combination that is new, and it is the delivery system that is what makes it able to be patented by a drug manufacturer. We don’t believe that you should have to wait for FDA approval to have access to retatrutide. When paired with a healthy diet, consistent exercise, accountability, and supervision, weight loss medications like retatrutide can be life-changing. But not all providers of weight loss shots are equal. Many peptides used at other clinics are sourced from China and other overseas. A spokesperson for Eli Lilly, the manufacturer of Mounjaro, told NBC that they’ve observed unsupervised Chinese manufacturers producing the active ingredients used in its medications. Many of these unauthorized manufacturers have no oversight from China's State Food and Drug Administration, making it impossible to know what is actually in your weight loss injections. At LIVation, we use weight loss injections that are sourced from a US-based peptide manufacturer. US-based peptide manufacturers are held to very high safety standards, including third party testing for purity. Our US-based peptide manufacturer custom-makes our weight loss shots to our specifications, creating blends of the weight loss peptides with nutrients designed to enhance weight loss. This helps reduce risk while simultaneously improving results. In fact, we have had multiple patients come to us from other providers stating that they felt much more effect from using LIVation treatments. We also offer complementary treatments, including Emsculpt , TriLift , IV therapy , and vitamin boosters that make you look and feel your best as you continue to lose weight. The Price of Retatrutide Weight Loss Injections at LIVation Retatrutide weight loss shots cost more than semaglutide and tirzepatide; no matter where you look, this is likely to be the case. It is a complex weight loss treatment and thus more expensive to manufacture. But we offer some of the best prices for retatrutide in Connecticut. At our Madison, CT clinic, retatrutide costs $800 to $2,400 for a month of treatment, depending on your dosing, which is customized to your exact needs. Your treatment also comes with weight loss counseling as well as access to our experienced and caring medical staff, who treat all of our patients like they’re family. We are transparent with our pricing because we don’t believe in “gatekeeping” weight loss, health, and wellness. The more information you have about your options for weight loss, the easier it is to make decisions about your health and begin your weight loss journey. The LIVation team is honored to guide you on that journey, whether you’re taking the first step or are already in progress. How to Get Retatrutide Weight Loss Shots Are you ready to learn more about retatrutide weight loss injections? The team of licensed medical professionals at LIVation is ready to help. Visit us in Madison, CT or contact us today to book your consultation and discover how retatrutide or our other weight loss shots could help you achieve your wellness goals.
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